Doctors

Educational experience

Graduated from the Fourth Military Medical University of the People's Liberation Army of China in 1986 with a Bachelor's degree in Medicine, went to the UK for further studies in 2003, obtained a PhD in Oncology from the University of Aberdeen in the UK in 2007, and completed postdoctoral work at the Sacramento Medical Center Stem Cell Transplantation Center at the University of California, Davis from 2008 to 2012.

work experience

Deputy Chief Physician of Hematology and Oncology at 309 Hospital of the People's Liberation Army. Later, he served as the Chief of the Medical Department and Deputy Director of the Medical Department of the 309 Hospital of the People's Liberation Army. From 2012 to 2017, engaged in research on tumor resistance and metastasis mechanisms at the University of Aberdeen School of Medicine in the UK. In 2010, he was appointed as a visiting professor at Peking University Cancer Hospital. In 2017, he served as the Executive Vice President of Hebei Yizhou Cancer Hospital.

Diagnosis and treatment expertise

I have been engaged in clinical, scientific research, and hospital management for 38 years, accumulating rich experience and conducting in-depth research on the clinical diagnosis and treatment of tumors, the mechanisms of tumor occurrence, tumor molecular diagnosis, and drug resistance mechanisms both domestically and internationally. I am particularly skilled in comprehensive tumor treatment. Especially in the research on the mechanisms of tumor metastasis and drug resistance, I have a high level of expertise and rich experience in the relationship between tumor genetic characteristics and prognosis. Published over 30 academic papers in domestic and foreign academic journals, including 24 in foreign journals.

Academic papers

· Lin Cao, Jie Liu, Jin Pu, Gillian Milne, Mei Chen, Heping Xu, Alan Shipley, John V Forrester,  Colin D McCaig, Noemi Lois, Polarized retinal pigment epithelium generates electrical signals that diminish with age and regulate retinal pathology, J Cell Mol Med 2018 Nov;22 (11): 5552-5564

· Cao L, Liu J, Pu J, Collinson JM, Forrester JV, McCaig CD, Endogenous bioelectric currents promote differentiation of the mammalian lens, J Cell Physiol. 2017 Jun 29. doi: 10.1002/jcp.26074. [Epub ahead of print]

· Yang, B., Cao, L., Liu, J., Xu, Y., Milne, G., Chan, W., Heys, SD., McCaig, CD. & Pu, J. (2015). Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancer. Cancer.  2015 May 15; 121(10): 1570–1580.

· Jin Pu, Lin Cao, Colin D McCaig (2015).  Physiological extracellular electrical signals guide and orient the polarity of gut epithelial cells, Tissue Barriers 02/2015; 3(3):e1037417.

· Lin Cao, Colin D McCaig, Jin Pu. Extracellular electric signals regulate neuroblast behaviours in adult brain (2015), Archives of Stem Cells & Research.

· Cao L, Pu J, Scott HR, Ching J, McCaig CD (2015).  Endogenous electrical signals in brain promote chain migration of neuroblasts through up-regulation of the purinergic receptor P2Y1. Stem Cell Rev. 2015 Feb;11(1):75-86.

· Cao L, McCaig CD, Scott HR, Zhao SW, Milne G, Clevers H, Zhao M, Pu J (2014). Polarizing intestinal epithelial cells electrically through Ror2. Journal of Cell Science. 127(Pt 15):3233-9.

· Cao L, Wei D, Reid B, Zhao S, Pu J, Pan T, Yamoah E, Zhao M (2013). Endogenous

electric currents might guide rostral migration of neuroblasts. EMBO Rep 14(2):184-

90. (This paper was highlighted as hot off the press and cover image).

·       Yang B, Cao L*, Liu B, McCaig CD, Pu J (2013). The transition from proliferation to

differentiation in colorectal cancer is regulated by the calcium activated chloride channel A1. PLoS One 8(4):e60861. (*Co-first author).

·       Vu Tran V, Zhang XD, Cao L, Li HQ, Lee BJ, Chen W, Zhao M (2013). Electrically increase transepithelial potentials -- targeting Na+/K+ pumps using synchronized electrical modulation. PLoS One 8(4):e61509.

· Zhao M, Chalmers L, Cao L, Vieira AC, Mannis M, Reid B (2012). Electrical signalling in control of ocular cell behaviors. Prog Retin Eye Res 31(1):65-88.

· Cao L, Graue-Hernandez EO, Tran V, Reid B, Pu J, Mannis MJ, Zhao M (2011).

Down-regulation of PTEN at corneal wound sites accelerates wound healing through increased cell migration. Invest Ophthalmol Vis Sci 52(5): 2272-2278.

· Cao L, Pu J, Zhao M (2011). GSK-3β is essential for physiological electric fields directed Golgi polarization. Cell Mol Life Sci 68(18):3081-93.

·       Vieira AC, Reid B, Cao L, Mannis MJ, Schwab JR, Zhao M (2011). Ionic components of electric current at rat corneal wounds. PLoS One 6(2):e17411.

·       Reid B, Vieira AC, Cao L, Mannis MJ, Schwab IR, Zhao M (2011). Specific ion fluxes generate cornea wound electric currents. Commun Integr Biol 4(4):462-5.

·       Cao L, Zhang XD, Liu X, Chen TY, Zhao M (2010). Chloride channels and transporters in human corneal epithelium. Exp Eye Res 90(6):771-9.

·       Tai G, Reid B, Cao L, Zhao M (2009). Electrotaxis and wound healing: experimental methods to study electric fields as a directional signal for cell migration. Methods

Mol Biol 571:77-97.

·        Pu J, McCaig CD, Cao L, Zhao ZQ, Segall JE, Zhao M (2007). Epidermal growth factor receptor signaling is essential for electric field directed migration of breast cancer cells. J Cell Sci 120(Pt 19):3395-403.

Academic Paper · Jie Chuanbin; Yang Tao; Wang Zishen; Fang Chunfeng; Xu Shouping; Cao Lin; Qu Baolin; Comparison of Dosimetry between Proton Intensity Modulated Radiotherapy and Two Photon Rotational Intensity Modulated Radiotherapy Technologies in Total Central Radiation, Medical and Health Equipment, Issue 05, 2021

·Fang Chunfeng, Hou Jun, Xu Shouping, Yang Tao, Qu Baolin, Cao Lin, Zhu Longlin, Jie Dong, Ji Dayue; Principles and Applications of Proton Therapy Systems, Chinese Medical Equipment, April 2021, Volume 18, Issue 4

·Yang Tao, Qu Baolin, Xu Shouping, Xie Chuanbin, Xu Wei, Gong Xuan, Cao Lin; Acceptance Test for Beam Performance of IBA Proton Pen Beam Scanning System, Chinese Journal of Radiation Oncology, December 15, 2020

·Yang Tao, Xu Shouping, Xie Chuanbin, Gong Xuan, Xu Wei, Qu Baolin, Prince Shen, Fang Chunfeng, Cao Lin; Quality evaluation of proton intensity modulated and photon volume rotation intensity modulated radiotherapy plans for prostate cancer [J]. Chinese Journal of Radiology and Protection, 2020,40 (1): 19-25

·Xu Wei; Yang Tao; Jie Chuanbin; Qu Baolin; Cao Lin; Wang Zishen; Song Yuanyuan; Fang Chunfeng; Xu Shouping; Comparison of Dosimetry between Proton Point Scanning Technology and Photon Tomotherapy in the Application of Prostate Cancer, Chinese Journal of Medical Physics, Issue 10, 2019

Research topic (overseas)

· Mechanisms of chemoresistance in solid tumours.

· Electrical control of retinal pigment epithelium and PEDF secretion: a new focus for treating age-related macular degeneration,

· The response of astrocytes to extracellular electrical signals (EES): Friend or Foe for CNS wound repair?

· Controlling Brain Tumours Electrically,

· SULSA Postdoctoral Exchange Scheme.

· A functional role for the transepithelial potential difference in cancer metastasis? -----Identification of electrically-regulated metastatic genes in breast cancer,